Tetrahydrobiopterin in ischemia and reperfusion injury


The essential co-factor of endothelial nitric oxide synthase (eNOS) tetrahydrobiopterin (BH4) has been repeatedly shown to protect transplanted organs from ischemia reperfusion injury (IRI). So far, the underlying mechanism has not been described. One hypothesis is that BH4 treatment prevents disruption of the functional nitric oxide producing form of eNOS, the so-called «uncoupling» and related superoxide production, by sustaining the dimeric status of the enzyme. Herein we tested this hypothesis in a murine transplantation model.



ISBN: 9783639628456
Вес: 501
Высота упаковки: 1
Глубина упаковки: 1
Год выпуска: 2014
Количество страниц: 88
Ширина упаковки: 1
Язык издания: Английский